Primary literature

Aggregated from every module. Click through to PubMed or the source publisher.

• What is a cell? — Conceptual perspective
  Alberts et al., Molecular Biology of the Cell, 7th ed.
  Module 01 · The Cell as a System
• The Human Cell Atlas: from vision to reality
  Regev et al., Nature 2017
  Module 01 · The Cell as a System
• The fluid mosaic model after 50 years
  Nicolson, BBA-Biomembranes 2014
  Module 02 · Membrane Biophysics & Transport
• Cryo-EM structures of Nav channels
  Pan et al., Science 2018
  Module 02 · Membrane Biophysics & Transport
• Highly accurate protein structure prediction with AlphaFold
  Jumper et al., Nature 2021
  Module 03 · Protein Structure, Folding & Quality Control
• Targeted protein degradation: from chemical biology to drug discovery
  Békés et al., Nat Rev Drug Discov 2022
  Module 03 · Protein Structure, Folding & Quality Control
• The cell biology of secretion
  Lippincott-Schwartz & Phair, Annu Rev Biophys 2010
  Module 04 · Organelles & the Secretory Pathway
• Lysosomal storage diseases
  Platt et al., Nat Rev Dis Primers 2018
  Module 04 · Organelles & the Secretory Pathway
• Microtubule dynamic instability
  Mitchison & Kirschner, Nature 1984
  Module 05 · Cytoskeleton & Cell Motility
• Mechanotransduction in cell biology
  Vogel & Sheetz, Nat Rev Mol Cell Biol 2006
  Module 05 · Cytoskeleton & Cell Motility
• Cell adhesion: the molecular basis of tissue architecture and morphogenesis
  Gumbiner, Cell 1996
  Module 06 · Cell Junctions & the Extracellular Matrix
• Mitochondria as signaling organelles
  Chandel, BMC Biology 2014
  Module 07 · Bioenergetics & Mitochondrial Cell Biology
• Mitochondrial replacement techniques
  HFEA UK guidance
  Module 07 · Bioenergetics & Mitochondrial Cell Biology
• Beyond the ligand: extracellular and transcellular G protein–coupled receptor signaling
  Heuberger & Roth, Annu Rev Pharmacol 2019
  Module 08 · Signal Transduction
• KRAS(G12C) inhibition with sotorasib
  Hong et al., NEJM 2020
  Module 08 · Signal Transduction
• The 4D nucleome project
  Dekker et al., Nature 2017
  Module 09 · Gene Expression & Chromatin
• Cancer epigenetics: from mechanism to therapy
  Dawson & Kouzarides, Cell 2012
  Module 09 · Gene Expression & Chromatin
• mRNA vaccines — a new era in vaccinology
  Pardi et al., Nat Rev Drug Discov 2018
  Module 10 · RNA Biology & Translation
• Splicing modulators in spinal muscular atrophy
  Mercuri et al., Lancet Neurol 2022
  Module 10 · RNA Biology & Translation
• Cyclin-dependent kinases as therapeutic targets in cancer
  Asghar et al., Nat Rev Drug Discov 2015
  Module 11 · Cell Cycle & Checkpoints
• Molecular mechanisms of cell death: recommendations 2018
  Galluzzi et al., Cell Death Differ 2018
  Module 12 · Cell Death Pathways
• Ferroptosis: an iron-dependent form of nonapoptotic cell death
  Dixon et al., Cell 2012
  Module 12 · Cell Death Pathways
• Synthetic lethal targeting of BRCA1/2 by PARP inhibitors
  Bryant et al., Nature 2005
  Module 13 · DNA Damage & Repair
• Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade
  Le et al., Science 2017
  Module 13 · DNA Damage & Repair
• Hallmarks of cancer: new dimensions
  Hanahan, Cancer Discov 2022
  Module 14 · Cancer Cell Biology
• Cancer cell plasticity: a renewed emphasis on drivers
  Quintanal-Villalonga et al., Nat Rev Clin Oncol 2020
  Module 14 · Cancer Cell Biology
• Induced pluripotent stem cells from adult human fibroblasts
  Takahashi et al., Cell 2007
  Module 15 · Stem Cells, Development & Regeneration
• Exagamglogene autotemcel for severe sickle cell disease
  Frangoul et al., NEJM 2024
  Module 15 · Stem Cells, Development & Regeneration
• Cancer immunotherapy using checkpoint blockade
  Ribas & Wolchok, Science 2018
  Module 16 · Cellular Immunology Essentials
• The cGAS-STING pathway as a therapeutic target
  Decout et al., Nat Rev Immunol 2021
  Module 16 · Cellular Immunology Essentials
• Search-and-replace genome editing without double-strand breaks (prime editing)
  Anzalone et al., Nature 2019
  Module 17 · Methods: Microscopy, Omics & Genome Editing
• The promise of single-cell transcriptomics
  Tanay & Regev, Nature 2017
  Module 17 · Methods: Microscopy, Omics & Genome Editing
• Gene therapy comes of age
  Dunbar et al., Science 2018
  Module 18 · Translational Frontier: Cell & Gene Therapy
• Tumor-infiltrating lymphocyte therapy for advanced melanoma (lifileucel)
  Chesney et al., J Immunother Cancer 2022
  Module 18 · Translational Frontier: Cell & Gene Therapy